The balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that triplets coding the same amino acid may well be rather similar.
Francis CrickFor simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the - class as having one too few.
Francis CrickIf Watson and I had not discovered the [DNA] structure, instead of being revealed with a flourish it would have trickled out and that its impact would have been far less. For this sort of reason Stent had argued that a scientific discovery is more akin to a work of art than is generally admitted. Style, he argues, is as important as content. I am not completely convinced by this argument, at least in this case.
Francis CrickThe dangerous man is the one who has only one idea, because then he'll fight and die for it.
Francis Crick