The emergence of a unified cognitive moment relies on the coordination of scattered mosaics of functionally specialized brain regions. Here we review the mechanisms of large-scale integration that counterbalance the distributed anatomical and functional organization of brain activity to enable the emergence of coherent behaviour and cognition. Although the mechanisms involved in large-scale integration are still largely unknown, we argue that the most plausible candidate is the formation of dynamic links mediated by synchrony over multiple frequency bands.

When a living system is suffering from ill health, the remedy is found by connecting with more of itself.

As Buddhist teachers often point out, knowledge, in the sense of prajña, is not knowledge about anything. There is no abstract knower of an experience that is separate from the experience itself.

I'm a biologist who has been interested in the biological roots of cognitive phenomena.

There is a strong current in contemporary culture advocating ' holistic ' views as some sort of cure-all... Reductionism implies attention to a lower level while holistic implies attention to higher level. These are intertwined in any satisfactory description: and each entails some loss relative to our cognitive preferences, as well as some gain... there is no whole system without an interconnection of its parts and there is no whole system without an environment.

All our suffering is associated with this pre-occupation. All loss and gain, pleasure and pain arise because we identify so closely with this vague feeling of selfness that we have. We are so emotionally involved with and attached to this "self" that we take it for granted.

The relations that define a system as a unity, and determine the dynamics of interaction and transformations which it may undergo as such a unity constitute the organization of the machine.