A DNA sequence for the genome of bacteriophage ΦX174 of approximately 5,375 nucleotides has been determined using the rapid and simple 'plus and minus' method. The sequence identifies many of the features responsible for the production of the proteins of the nine known genes of the organism, including initiation and termination sites for the proteins and RNAs. Two pairs of genes are coded by the same region of DNA using different reading frames.

Influenced by him, and probably even more so by my brother Theodore a year older than me, I soon became interested in biology and developed a respect for the importance of science and the scientific method.

It is like a voyage of discovery into unknown lands, seeking not for new territory but for new knowledge. It should appeal to those with a good sense of adventure.

And indeed this theme has been at the centre of all my research since 1943, both because of its intrinsic fascination and my conviction that a knowledge of sequences could contribute much to our understanding of living matter.

When I was young my Father used to tell me that the two most worthwhile pursuits in life were the pursuit of truth and of beauty and I believe that Alfred Nobel must have felt much the same when he gave these prizes for literature and the sciences.

Initially I had intended to study medicine, but before going to University I had decided that I would be better suited to a career in which I could concentrate my activities and interests more on a single goal than appeared to be possible in my father's profession.

I and my colleagues here have been engaged in the pursuit of knowledge.