The biggest breakthrough in the next 50 years will be the discovery of extraterrestrial life. We have been searching for it for 50 years and found nothing. That proves life is rarer than we hoped, but does not prove that the universe is lifeless. We are only now developing the tools to make our searches efficient and far-reaching, as optical and radio detection and data processing move forward.

One of the memorable moments of my life was when Willard Libby came to Princeton with a little jar full of crystals of barium xenate. A stable compound, looking like common salt, but much heavier. This was the magic of chemistry, to see xenon trapped into a crystal.

New directions in science are launched by new tools much more often than by new concepts. The effect of a concept-driven revolution is to explain old things in new ways. The effect of a tool-driven revolution is to discover new things that have to be explained.

Walking the streets of Tokyo with Hawking in his wheelchair ... I felt as if I were taking a walk through Galilee with Jesus Christ [as] crowds of Japanese silently streamed after us, stretching out their hands to touch Hawking's wheelchair. ... The crowds had streamed after Einstein [on Einstein's visit to Japan in 1922] as they streamed after Hawking seventy years later. ... They showed exquisite choice in their heroes. ... Somehow they understood that Einstein and Hawking were not just great scientists, but great human beings.

You ask: what is the meaning or purpose of life? I can only answer with another question: do you think we are wise enough to read God's mind?

Science is my territory, but science fiction is the landscape of my dreams.

The only way to improve the chances for finding winners is to keep all the choices open and try them all.