To understand the Universe, you must understand the language in which it's written, the language of Mathematics.

It has always seemed to me extreme presumptuousness on the part of those who want to make human ability the measure of what nature can and knows how to do, since, when one comes down to it, there is not one effect in nature, no matter how small, that even the most speculative minds can fully understand.

With regard to matters requiring thought: the less people know and understand about them, the more positively they attempt to argue concerning them.

The surface of the Moon is not smooth, uniform, and precisely spherical as a great number of philosophers believe it to be, but is uneven, rough, and full of cavities and prominences, being not unlike the face of the Earth, relieved by chains of mountains and deep valleys.

The Grand Duke [of Tuscany] ...after observing the Medicaean plants several times with me ... has now invited me to attach myself to him with the annual salary of one thousand florins, and with the title of Philosopher and Principal Mathematicial to His Highness; without the duties of office to perform, but with the most complete leisure; so that I can complete my Treatises.

Holy Writ was intended to teach men how to go to Heaven not how the heavens go.

I have been judged vehemently suspect of heresy, that is, of having held and believed that the sun in the centre of the universe and immoveable, and that the earth is not at the center of same, and that it does move. Wishing however, to remove from the minds of your Eminences and all faithful Christians this vehement suspicion reasonably conceived against me, I abjure with a sincere heart and unfeigned faith, I curse and detest the said errors and heresies, and generally all and every error, heresy, and sect contrary to the Holy Catholic Church. (Quoted in Shea and Artigas 194)