Discount the obvious, bet on the unexpected
It is much easier to put existing resources to better use, than to develop resources where they do not exist.
My main concern is with the world order
My original intention was to spend the money in my lifetime.
The main difference between me and other people who have amassed this kind of money is that I am primarily interested in ideas, and I don't have much personal use for money.
The assumption of perfect knowledge is very far from reality ... a lot of the evil in the world is actually not intentional.