Britain can be proud of its response to the tsunami appeal.

The doubling of oil prices ... is creating a more difficult environment in which to act.

We are entering an era in which national government, instead of directing, enables powerful regional and local initiatives to work, where Britain becomes as it should be - a Britain of nations and regions.

We are being tough in saying it is a duty on the unemployed in future not only to be available for work - and not to shirk work - but also to get the skills for work. That is a new duty we are introducing.

I will listen and I will learn. I will strive to meet people's aspirations. I want to lead a government humble enough to know its place - where I will always strive to be - and that is on people's side.

Indeed, Britain was set to repeat the old, familiar cycle of boom and bust. Since then, we have created and rigorously adhered to a new framework of modern economic management

Britain should be the world's number one center for genetic and stem cell research, building on our world leading regulatory regime in the area.