The use of thermodynamics in biology has a long history rich in confusion.
The probability for the chance of formation of the smallest, simplest form of living organism known is 1 to 10340,000,000.... The size of this figure is truly staggering, since there are only supposed to be approximately 10 electrons in the whole universe!
The flow of energy through a system acts to organize that system.
Computer science is to biology what calculus is to physics. It's the natural mathematical technique that best maps the character of the subject.