Failures are inevitable. Unfortunately, in film they live for ever and they're 40 ft wide and 20 ft high.

Because the character is a fiction, he's a composite of other contributors to the science that brought this enzyme therapy through the process. We had the opportunity to make him up out of those things that helped tell the story. We wanted to create both ally and antagonist for John [in the Extraordinary measures].

We have been led to believe that we have come a long way toward world nuclear disarmament. But that is not the case. Our government is not doing all that it could. We must urge our leaders to fulfill the obligations of the Nuclear Non-Proliferation Treaty. The United States must assume world leadership to end once and for all the threat of nuclear war. It is our moral responsibility.

I've never been bothered by proximity to special effects and I've never felt disadvantaged by them. They're all part of a movie, and when the movie's under control I don't feel upstaged by them.

My ambition from the very beginning was to make a good part for myself, something differently to what lately I've been doing.

It's time to change the conversation about nature to focus on what we all have in common: our shared humanity.

There comes a point when you've exhausted your opportunities playing good guys. I've been around long enough, I think I'm entitled to explore a bit. But what I saw there was an opportunity to play a character different from what the audience's expectation was. A chance to take their crude experience of me - of my iconography, if you will - and turn it on its ear at an appropriate juncture in the film to be useful to the process of telling the story.