Bikes and planes aren’t about going fast or having fun; they’re toys, but serious ones.

I accrued anger from people's low opinion of me and my work, and for the work I might be capable of.

Because the character is a fiction, he's a composite of other contributors to the science that brought this enzyme therapy through the process. We had the opportunity to make him up out of those things that helped tell the story. We wanted to create both ally and antagonist for John [in the Extraordinary measures].

Work hard and figure out how to be useful and don't try to imitate anybody else's success. Figure out how to do it for yourself with yourself.

Hell of a thing when a man's got good health, plenty of money and absolutely nothing to do.

If I were a serious person, I'd probably have a real job.

You always have to know what the ambition of the scene is, what the purpose of that scene is in the telling of the story overall, so that you're there to support the story.