It's important not to base your ambition on anybody else's history, but to figure out how best to use your own particular personality and understanding of yourself to help tell other people's stories.

Nothing shocks me. I'm a scientist.

You have to have a darkness...for the dawn to come. You have to have experienced difficulties and challenges to fully appreciate and be grateful for success.

Because the character is a fiction, he's a composite of other contributors to the science that brought this enzyme therapy through the process. We had the opportunity to make him up out of those things that helped tell the story. We wanted to create both ally and antagonist for John [in the Extraordinary measures].

Henry: Well I'm sorry about your head though, but I thought you were one of them. Indiana: Dad, they come in through the doors.

My ambition from the very beginning was to make a good part for myself, something differently to what lately I've been doing.

I've always wanted to be bald. I mean it, completely bald. Wouldn't it be great to be bald in the rain?