With the CGI, suddenly there's a thousand enemies instead of six - the army goes off into the horizon. You don't need that. The audience loses its relationship with the threat on the screen. That's something that's consistently happening and it makes these movies like video games and that's a soulless enterprise. It's all kinetics without emotion.

Because the character is a fiction, he's a composite of other contributors to the science that brought this enzyme therapy through the process. We had the opportunity to make him up out of those things that helped tell the story. We wanted to create both ally and antagonist for John [in the Extraordinary measures].

It doesn't interest me to be Harrison Ford. It interests me to be Mike Pomeroy and Indiana Jones and Jack Ryan. I don't want to be in the Harrison Ford business. I take what I do seriously, but I don't take myself seriously.

I get an opportunity to communicate with the audience about the movie that I've made. I get the chance to bring attention to the film that I've made. I care a lot about the movies that I make. I want them to reach an audience, and I want them to be successful. I promote nearly everything that I do, unless I've got some bad taste in my mouth.

I am my age. I'm not making any effort to change it.

Starring in a science-fiction film doesn't mean you have to act science fiction.

We all have big changes in our lives that are more or less a second chance.