The landscape has been so totally changed, the ways of thinking have been so deeply affected, that it is very hard to get hold of what it was like before… It is very hard to realize how total a change in outlook Isaac Newton has produced.

If you walk along the street you will encounter a number of scientific problems. Of these, about 80 per cent are insoluble, while 19½ per cent are trivial. There is then perhaps half a per cent where skill, persistence, courage, creativity and originality can make a difference. It is always the task of the academic to swim in that half a per cent, asking the questions through which some progress can be made.

... an opportunity to allow the bees in one's bonnet to buzz even more noisily than usual.

The true contrast between science and religion is that science unites the world and makes it possible for people of widely differing backgrounds to work together and to cooperate. Religion, on the other hand, by its very claim to know “The Truth” through “revelation,” is inherently divisive and a creator of separatism and hostility.

The scientist … must always be prepared to deal with the unknown. It is an essential part of science that you should be able to describe matters in a way where you can say something without knowing everything.

[Science doesn't deal with facts; indeed] fact is an emotion-loaded word for which there is little place in scientific debate.

On the most usual assumption, the universe is homogeneous on the large scale, i.e. down to regions containing each an appreciable number of nebulae. The homogeneity assumption may then be put in the form: An observer situated in a nebula and moving with the nebula will observe the same properties of the universe as any other similarly situated observer at any time.