There's the continuing challenges of racism, of sexism, of discrimination against the LGBT community, of the way that we treat people as opposed to how we want to be treated.

What I found when I became Secretary of State was a lot of doubts and a lot of concerns and fears from friends, allies, around the world.

There is no nation on the planet better able to adapt to this change than our nation. We must able to work collaboratively with others. We must anticipate these threats before they happen. This is the new sort of challenge, the new sort of threat that does, in fact, require new thinking, fresh approaches and new leadership.

It's true that America can't solve every problem, but I don't know of any major problem in the world that can be solved without us.

I do. You know, I made a mistake using a private e- mail.

My own country's record on human rights for gay people is far from perfect.

You know, everybody has setbacks in their life, and everybody falls short of whatever goals they might set for themselves. That's part of living and coming to terms with who you are as a person.