I think whoever runs next time has to have a very clear idea of where he or she wants to take America and has to run on those ideas, because the election cannot be about personalities, participants sniping, all of the irrelevant stuff the day after the election sort of dissipates, and you wake up and say, okay, now what am I going to do?

The president [Barack Obama] himself has said he thought part of his job was to remind the American people that being president and commander in chief is a serious responsibility.

I voted for every sanction against Iran when I was in the Senate, but it wasn't enough. So I spent a year-and-a-half putting together a coalition that included Russia and China to impose the toughest sanctions on Iran.

We all have to do our part, because we are all in this together and it matters.

We have to restore trust between communities and the police.

Every time I meet somebody who's been affected by something I worked on, I feel like, yes, that's what I want to do, whether the Children's Health Insurance Program or making drugs safer for kids or helping more kids get a doctor, whatever it might be.

Climate change is such a consequential crisis to everybody in the world.