The brain of man, like that of all animals is double, being parted down its centre by a thin membrane. For this reason pain is not always felt in the same part of the head, but sometimes on one side, sometimes on the other, and occasionally all over.
HippocratesIt is changes that are chiefly responsible for diseases, especially the greatest changes, the violent alterations both in the seasons and in other things. (:)...regimen and temperature, and one period of life to another.
Hippocrates