I never was someone who was at ease with happiness.

As a real person, he wouldn't last a minute, would he? But drama is about imperfection. And we've moved away from the aspirational hero. We got tired of it, it was dull. If I was House's friend, I would hate it. How he so resolutely refuses to be happy or take the kind-hearted road. But we don't always like morally good people, do we?

Driving a motorcycle is like flying. All your senses are alive. When I ride through Beverly Hills in the early morning, and all the sprinklers have turned off, the scents that wash over me are just heavenly. Being House is like flying, too. You're free of the gravity of what people think.

One thing House needs Wilson for is vanity. He needs someone to laugh at his jokes.

I have resolved to pick one novel and just read it over and over again for the rest of my life, because I cannot remember anything anymore.

Success on a cosmic level completely eludes me. I'm deeply suspicious of things being too good. It's part of my superstition, I think, to generate pain in order to give the illusion of gain. I'm not saying I reject success, but honestly, I don't quite know how to deal with it. It's an old feeling: As soon as you have the thing you've been going after all your life, that reasonable degree of security, you start kicking against it, doubting it.

I think good-looking people seldom make good television. And American television studios almost concede before they start: 'Well, it won't be good, but at least it'll be good-looking. We'll have nice-looking girls in tight shirts with F.B.I. badges and fit-looking guys with lots of hair gel vaulting over things.'