The Synthesis consists in assuming the Causes discovered and established as Principles, and by them explaining the Phænomena proceeding from them, and proving the Explanations.

In the absence of any other proof, the thumb alone would convince me of God's existence.

To explain all nature is too difficult a task for any one man or even for any one age

To any action there is always an opposite and equal reaction; in other words, the actions of two bodies upon each other are always equal and always opposite in direction.

A Vulgar Mechanick can practice what he has been taught or seen done, but if he is in an error he knows not how to find it out and correct it, and if you put him out of his road he is at a stand. Whereas he that is able to reason nimbly and judiciously about figure, force, and motion, is never at rest till he gets over every rub. (from a letter dated 25 May, 1694)

Live your life as an Exclamation rather than an Explanation

Nature does nothing in vain when less will serve; for Nature is pleased with simplicity and affects not the pomp of superfluous causes.