The best and safest way of philosophising seems to be, first to enquire diligently into the properties of things, and to establish those properties by experiences [experiments] and then to proceed slowly to hypotheses for the explanation of them. For hypotheses should be employed only in explaining the properties of things, but not assumed in determining them; unless so far as they may furnish experiments.

All material Things seem to have been composed of the hard and solid Particles ... variously associated with the first Creation by the Counsel of an intelligent Agent. For it became him who created them to set them in order: and if he did so, it is unphilosophical to seek for any other Origin of the World, or to pretend that it might arise out of a Chaos by the mere Laws of Nature.

What we know is a drop, what we don't know is an ocean.

The seed of a tree has the nature of a branch or twig or bud. It is a part of the tree, but if separated and set in the earth to be better nourished, the embryo or young tree contained in it takes root and grows into a new tree.

You ask me how, with so much study, I manage to retene my health. Morpheus is my last companion; without 8 or 9 hours of him yr correspondent is not worth one scavenger's peruke. My practices did at ye first hurt my stomach, but now I eat heartily enou' as y' will see when I come down beside you.

In the absence of any other proof, the thumb alone would convince me of God's existence.

To explain all nature is too difficult a task for any one man or even for any one age