I can measure the motion of bodies but I cannot measure human folly.

I have not been able to discover the cause of those properties of gravity from phenomena, and I frame no hypotheses; for whatever is not deduced from the phenomena is to be called a hypothesis, and hypotheses, whether metaphysical or physical, whether of occult qualities or mechanical, have no place in experimental philosophy.

You have to make the rules, not follow them

I can see so far because I stood on the shoulders of giants.

A cylinder of air reaching to the top of the atmosphere is of equal weight with a cylinder of water about 33 feet high.

I am ashamed to tell you to how many figures I carried these calculations [of Pi], having no other business at the time

How came the bodies of animals to be contrived with so much art, and for what ends were their several parts? Was the eye contrived without skill in Opticks, and the ear without knowledge of sounds?...and these things being rightly dispatch’d, does it not appear from phænomena that there is a Being incorporeal, living, intelligent...?