In the dog two conditions were found to produce pathological disturbances by functional interference, namely, an unusually acute clashing of the excitatory and inhibitory processes, and the influence of strong and extraordinary stimuli. In man precisely similar conditions constitute the usual causes of nervous and psychic disturbances. Different conditions productive of extreme excitation, such as intense grief or bitter insults, often lead, when the natural reactions are inhibited by the necessary restraint, to profound and prolonged loss of balance in nervous and psychic activity.

It is not accidental that all phenomena of human life are dominated by the search for daily bread - the oldest link connecting all living things, man included, with the surrounding nature.

If we could look through the skull into the brain of a consciously thinking person, and if the place of optimal excitability were luminous, then we should see playing over the cerebral surface, a bright spot with fantastic, waving borders constantly fluctuating in size and form, surrounded by a darkness more or less deep, covering the rest of the hemisphere.

Possibilities are like the wings of birds; they allow man to soar and to climb to the heavens. And facts are like the atmosphere against which those wings must beat, and without which the soaring bird will surely plummet back to earth.

One can truly say that the irresistible progress of natural science since the time of Galileo has made its first halt before the study of the higher parts of the brain, the organ of the most complicated relations of the animal to the external world. And it seems, and not without reason, that now is the really critical moment for natural science; for the brain, in its highest complexity-the human brain-which created and creates natural science, itself becomes the object of this science.

The digestive canal represents a tube passing through the entire organism and communicating with the external world, i.e. as it were the external surface of the body, but turned inwards and thus hidden in the organism.

But man has still another powerful resource: natural science with its strictly objective methods.