[John] Dalton was a man of regular habits. For fifty-seven years he walked out of Manchester every day; he measured the rainfall, the temperature-a singularly monotonous enterprise in this climate. Of all that mass of data, nothing whatever came. But of the one searching, almost childlike question about the weights that enter the construction of these simple molecules-out of that came modern atomic theory. That is the essence of science: ask an impertinent question, and you are on the way to the pertinent answer.

Satire is not a social dynamite. But it is a social indicator: it shows that new men are knocking at the door.

Dream or nightmare, we have to live our experience as it is, and we have to live it awake. We live in a world which is penetrated through and through by science and which is both whole and real. We cannot turn it into a game simple by taking sides.

When Da Vinci wanted an effect, he willed, he planned the means to make it happen: that was the purpose of his machines. But the machines of Newton ... are means not for doing but for observing. He saw an effect, and he looked for its cause.

The most powerful drive in the ascent of man is his pleasure in his own skill. He loves to do what he does well and, having done it well, he loves to do it better. You see it in his science. You see it in the magnificence with which he carves and builds, the loving care, the gaiety, the effrontery. The monuments are supposed to commemorate kings and religions, heroes, dogmas, but in the end the man they commemorate is the builder.

The most remarkable discovery ever made by scientists is science itself. The discovery must be compared in importance with the invention of cave-painting and of writing.

It doesn't matter whether you're talking about bombs or the intelligence quotients of one race as against another if a man is a scientist, like me, he'll always say Publish and be damned.