Peer reviewers go for orthodoxy ... Many of the great 19th-century discoveries were made by men who had independent wealth-Charles Darwin is the prototype. They trusted themselves.

The techniques have galloped ahead of the concepts. We have moved away from studying the complexity of the organism; from processes and organisation to composition.

I did help to set up an undergraduate course in medicinal chemistry and made progress in modelling and analysing pharmacological activity at the tissue level, my new passion.

We paid off our debts, we learned some, made friends and returned in 1950 with a larger view of life. I had, however, no home, no income of any kind and no prospects whatsoever.

I wish I had my beta-blockers handy.

I learnt, for the first time, the joys of substituting hard, disciplined study for the indulgence of day-dreaming.

I met Hilary Vaughan at a Student Ball in 1944 and we married in the summer of 1946, as soon as I graduated.