With the MacArthur grant, I realized that people have high expectations of me, that they were placing me in this group of achievers. I compared what Id actually achieved in my life with what I would like to achieve and what other people have achieved, and I found that comparison depressing.

Some people have much more pull than other people. But when I say that the public has ultimate responsibility, I'm not saying it in a moral sense. I'm just saying it in the sense of what is it that's really going to bring change.

It invites a search for ultimate causes: why were Europeans, rather than Africans or Native Americans, the ones to end up with guns, the nastiest germs, and steel?

The southward advance of native African farmers with Central African crops halted in Natal, beyond which Central African crops couldn't grow - with enormous consequences for the recent history of South Africa.

I personally am not conscious of my accent.

To science we owe dramatic changes in our smug self-image. Astronomy taught us that our Earth is not the center of the universe, but merely one of nine planets circling one of billions of stars. From biology we learned that humans were not specially created by God but evolved along with tens of millions of other species.

The survival rate of Dr Burton's patients approximately doubled the maximum survival rate of conventionally treated patients. Had these findings pertained to a chemotherapy drug instead of IAT, massive amounts of funding would have been allocated to investigate the drug. Once again, the politics of cancer barred a potentially valuable treatment from reaching the public.