Disruptors don't have to discover something new; they just have to discover a practical use for new discoveries.
A career is just a longer trip with a whole lot more baggage.
Be the best at what you do or the only one doing it.
Crowdsourcing is the ultimate disruptor of distribution because in a most Zen-like fashion, the content is controlled by everyone and no one at the same time.
No obstacle is so big that one person with determination can't make a difference.
You will have more regrets for the things you didn't try than the ones you tried and didn't succeed at.