All behavioral or mood disorders - including depression, OCD, ADHD and addiction - have some neurochemical components, but sufferers can still work to overcome them.

As MBA professors endlessly tell their students, companies do best when they stick to what they do well. There's a reason Apple doesn't make blenders. There's a reason Haagen-Dazs doesn't sell meat. And there's a reason drug companies should focus on saving and improving lives - not jeopardizing them.

A child gets vaccinated and soon after, autism symptoms emerge. The apparent cause-and-effect is understandable but erroneous - more a coincidence of the calendar and childhood developmental stages than anything else, as repeated and exhaustive studies have shown.

Confidence quickly curdles into arrogance; smarts turn to smugness, charm turns to smarm.

I grew up in a suburb of Baltimore with an extremely high concentration of Jewish families - where the Levys and Cohens in the high school yearbook went on for pages, where I could count far more temples than I ever could churches. Anti-Semitism, in our cultural biodome, was mostly an abstract concept.

Paul McCartney had a baby when he was 61; Rod Stewart was 66; Rupert Murdoch was a stunning 72. Not only does that mean they'll have less stamina than the average dad, that means they'll, well, check out a lot sooner too.

It's far too much to say that effective hoping is the only - or even the biggest - part of what it takes to succeed. If 14% of business productivity can be attributed to hope, that means 86% is dependent on raw talent, fickle business cycles, the quality of the product you're selling, and often pure, dumb luck.