Hope, true hope, has proved as important as any medication I might prescribe or any procedure I might perform.

Many years before when I had serious back pain from a sports injury, the surgeons said they would explore my spine and "figure it out." Out of frustration I had impulsively opted for the procedure. They ended up fusing the vertebrae. It left me debilitated. In hindsight, I blamed myself more than the surgeons. I had pressed them for a solution when in fact none was apparent because the cause of the pain was obscure.

There is an authentic biology of hope. Belief and expectation - the key elements of hope - can block pain by releasing the brain's endorphins and enkephalins, mimicking the effects of morphine.

Help, then, is the ballast that keeps us steady, that recognizes where along the path are the dangers and pitfalls that can throw us off; hope tempers fear so we can recognize dangers and then bypass or endure them.

Hope gives us the courage to confront our circumstances and the capacity to surmount them.

On average, physicians interrupt patients within eighteen seconds of when they begin telling their story.

I feel that I have to do everything better just to be judged as okay. It is something I wish I could let go of. It's something that I wish just wasn't there.