This is something that the nimblest standup comedians learn, over time, to handle gracefully. They'll go between prepared material, then they'll respond to what's happening in the room and weave it back into the prepared material and so on.
John HodgmanComedy does offer an avenue to television and film careers for untelegenic people that great drama does not.
John HodgmanWhy certain political classes want purposefully to keep Americans in a state of perpetual debt and uncertainty and why certain people don't want a middle class - because middle class creates a certain happiness. You know what I mean?
John Hodgman