You have to decide what those issues are for you. What do you think disqualifies a person from holding public office? I believe that the endorsement of the right to kill unborn children disqualifies a person from any position of public office. It's simply the same as saying that the endorsement of racism, fraud, or bribery, would disqualify him - except that child-killing is more serious than those.
John PiperThe ultimate difference between God's wisdom and man's wisdom is how they relate to the glory of God's grace in Christ crucified. God's wisdom makes the glory of God's grace our supreme treasure. But man's wisdom delights in seeing himself as resourceful, self-sufficient, self determining, and not utterly dependent on God's free grace.
John PiperThe main reason God has given us minds is that we might seek out and find all the reasons that exist for treasuring him in all things and above all things.
John PiperGod is pursuing with omnipotent passion a worldwide purpose of gathering joyful worshipers for Himself from every tribe and tongue and people and nation. He has an inexhaustible enthusiasm for the supremacy of His name among the nations. Therefore, let us bring our affections into line with His, and, for the sake of His name, let us renounce the quest for worldly comforts and join His global purpose.
John Piper