Bottom up thinkers try to start from experience and move from experience to understanding. They don't start with certain general principles they think beforehand are likely to be true; they just hope to find out what reality is like.
John PolkinghorneGod is not a God of the edges, with a vested interest in beginnings. God is the God of the whole show.
John PolkinghorneThe test of a theory is its ability to cope with all the relevant phenomena, not its a priori 'reasonableness'. The latter would have proved a poor guide in the development of science, which often makes progress by its encounter with the totally unexpected and initially extremely puzzling.
John Polkinghorne