When a liver becomes cirrhotic, those are the common complications. We see that the patients have bleeding from their stomach and intestines. They have abdomens that become full of fluid. Their ankles swell with the same type of fluid, and they also can become confused and not themselves. Those are kind of the main things that we see when people get end-stage liver disease and have cirrhosis.
John RobertsI'm not sure that it's right to view this as excluding a particular group. When the institution of marriage developed historically, people didn't get around and say, 'Let's have this institution, but let's keep out homosexuals.' The institution developed to serve purposes that, by their nature, didn't include homosexual couples.
John RobertsIf the Constitution says that the little guy should win, the little guy is going to win in court before me, ... But if the Constitution says that the big guy should win, well, then the big guy is going to win because my obligation is to the Constitution.
John RobertsWhen we think about living donor transplant, what we're banking on is the ability of the liver to regenerate itself. Now, it's not the same sort of regeneration we think about with the starfish where we cut off the arm and it grows a new arm. With the liver, what happens is the remaining liver gets bigger, and your body knows the size of the liver that it needs, and when it recognizes that there is not enough liver, it sends nutrients and signals to the liver and says "get bigger."
John RobertsThere is a risk of death associated with donating a piece of liver. It's about one in 500 for the risk of death. The risk of death of donating a kidney is about one in 3000, so this is a riskier operation than donating a kidney. The stakes are usually higher for the recipient of the transplant because unlike kidney failure, where you have a dialysis machine, in liver failure we don't have that kind of machine that allows a patient to survive until they can get a cadaver organ.
John RobertsPretty much everybody knows there are not enough organs for all of those patients who need to get transplants, and what happens is, is that organs are actually directed in liver transplantation to those patients who are the sickest. So the patients who have the greatest chance of dying in the next three months or so are the ones who get the priority for the liver transplant.
John Roberts