Our visual cortexes are wired to quickly recognize faces and then quickly subtract massive amounts of detail from them, zeroing in on their essential message: Is this person happy? Angry? Fearful? Individual faces may vary greatly, but a smirk on one is a lot like a smirk on another. Smirks are conceptual, not pictorial. Our brains are like cartoonists - and cartoonists are like our brains, simplifying and exaggerating, subordinating facial detail to abstract comic concepts.

Depression, when it's clinical, is not a metaphor. It runs in families, and it's known to respond to medication and to counseling. However truly you believe there's a sickness to existence that can never be cured, if you're depressed you will sooner or later surrender and say: I just don't want to feel bad anymore. The shift from depressive realism to tragic realism, from being immobilized by darkness to being sustained by it, thus strangely seems to require believing in the possibility of a cure.

I wrote two plotted books, got some of the fundamentals of storytelling down, then... it's sort of like taking the training wheels off, trying to write a book that's fun in the same way without relying on quite such mechanical or external beats.

The more you pursue distractions, the less effective any particular distraction is, and so I'd had to up various dosages, until, before I knew it, I was checking my e-mail every ten minutes, and my plugs of tobacco were getting ever larger, and my two drinks a night had worsened to four, and I'd achieved such deep mastery of computer solitaire that my goal was no longer to win a game but to win two or more games in a row--a kind of meta-solitaire whose fascination consisted not in playing the cards but in surfing the streaks of wins and losses.

[T]hat I could find company and consolation and hope in an object pulled almost at random from a bookshelf--felt akin to an instance of religious grace.

There's a hazardous sadness to the first sounds of someone else's work in the morning; it's as if stillness experiences pain in being broken.

I don't personally like the e-readers they've come up with so far. I don't fetishize books, but I do like that they're solid and unchanging.