Depression, when it's clinical, is not a metaphor. It runs in families, and it's known to respond to medication and to counseling. However truly you believe there's a sickness to existence that can never be cured, if you're depressed you will sooner or later surrender and say: I just don't want to feel bad anymore. The shift from depressive realism to tragic realism, from being immobilized by darkness to being sustained by it, thus strangely seems to require believing in the possibility of a cure.

she was so much a personality and so little anything else that even staring straight at her he had no idea what she really looked like.

Patty knew, in her heart, that he was wrong in his impression of her. And the mistake she went to go on to make, the really big life mistake, was to go along with Walter's version of her in spite of knowing that it wasn't right. He seemed so certain of her goodness that eventually he wore her down.

Walter had never liked cats. They'd seemed to him the sociopaths of the pet world, a species domesticated as an evil necessary for the control of rodents and subsequently fetishized the way unhappy countries fetishize their militaries, saluting the uniforms of killers as cat owners stroke their animals' lovely fur and forgive their claws and fangs. He'd never seen anything in a cat's face but simpering incuriosity and self-interest; you only had to tease one with a mouse-toy to see where it's true heart lay...cats were all about using people

Twitter is unspeakably irritating. Twitter stands for everything I oppose.

Family's the one thing you can't change. You can cover yourself with tattoos. You can get a grapefruit-sized ring going through your earlobe. You can change your name. You can move to a different continent. But you cannot change who your parents were, and who your siblings are, and who your children are.

If you're interested in how people behave, if you're interested in the way they talk about themselves, the way the conceive of themselves, it's very hard to ignore drugs nowadays, because that is so much part of the conversation.