Yet for all the depression no one ever quit. When someone quit, we couldn't believe it. 'I'm becoming a rafting instructor on the Colorado River,' they said. 'I'm touring college towns with my garage band.' We were dumbfounded. It was like they were from another planet. Where had they found the derring-do? What would they do about car payments? We got together for going away drinks on their final day and tried to hide our envy while reminding ourselves that we still had the freedom and luxury to shop indiscriminately.

She looks at herself in the mirror. The idea is to look sexy again. And for whom exactly? Yourself, of course. Yes, well, that's all wonderfully self-affirming and very strong-minded as any decent woman should be these days, but let's just face facts here and say that when a woman - no, when a person is thinking about feeling sexy, it is always with the idea of someone else in mind.

Being serious is serious business in fiction. It's commercial or hoi polloi in fiction to be funny. It's too accessible to the great unwashed.

If you can get by with quotes from The Godfather and nothing you say matters, that's pretty bleak, don't you think? Don't we want what we say to matter?

There were times where I felt I was pressing a little bit too hard with the humor, and I had to pull back, because the overriding concern of the book was to create this disease that had no cure and make you pay attention to every emotional stage of what happens.

Comedy is like fictional charm. It's the charm of fiction. Or the charisma of fiction. When you meet somebody who's immediately charismatic, you're attracted to that person. And in fiction it's got to come out in either one of two ways: in the prose itself, and you're hooked immediately because you never want to leave such a colorful and penetrating world. Or, it's simply being a funny writer.

All broken hearts are circumstantial. Every lovelorn jerk is the victim of bad timing, good intentions, and someone else’s poor decision making.