There's always a question when you invest. Are you too early, are you too late, or are you just right? And there was a lot of hype about life sciences, around the sequencing of the human genome and a lot of people concluded that's not really there. But by the way, there was a lot of hype around the digital revolution just about the time of 2000 and the human genome, and it turns out that some of the world's biggest, most powerful companies are the survivors post that crash.

I've always been interested in why countries appear and disappear. And the curious thing is how often it happens.

Borlaug would be one figure that I think fundamentally changed India, China, all of Southeast Asia, and gave them the time to be able to build on other things.

It's not fear that keeps me up. I mean, every generation has thought, this is the worst generation; the world's going to hell in a hand basket. The reality is, people are living longer, and they're living better.

There's a creativity, a power, an energy, an ability to do things unlike any other period in history. It's a little bit like sitting in the Renaissance, but multiplied a thousand-fold.

The definition of who's literate and who's not keeps changing. So, in Neanderthal times, if you painted on a cave wall, that was enough to transmit how you hunt, how you eat, how you cook, how you dress, and we can read about that.

After a lot of debate and a lot of work, what people decided is, it makes a great deal of sense to be open in the system and allow people to begin to build better flu vaccines. I mean, we're still making them in eggs that come out of chickens. And we can see the consequences of that with the current H1N1 lack of vaccines.