Ask your friends how many stars will be in the U.S. flag in 50 years? And the reason why that's a reasonable question is because there has never been a President of the United States who's been buried under the same flag he was born under.

Anytime you bring a really powerful new technology to market there are multiple implications. You start changing the relative position of countries.

There are certain zip codes that generate a disproportionate share of patents, of startups, of wealth, of jobs. And it's really important if other parts of the country are going to want to create these tech centers.

The housing crisis may not be the worst thing that's happened to New York City because it was becoming impossible for some of the young doctors, for some of the young artists, for some of the people that make the city so special to be able to live here.

It's such an extraordinary time to be alive that you just don't want to miss it. I mean, it's a really neat historical period.

If you don't have that science and technology and brains as an input, as you don't have in large parts of Latin America, if you don't focus your education on that, if you don't find your 10,000 best scientists, but you do find your 10,000 best soccer players, the consequences are, you become a World Cup Champion in Soccer, like Brazil, but you don't become Korea, which earned 1/5 of what a Mexican did in 1975 and today earns five times more.

There's always a question when you invest. Are you too early, are you too late, or are you just right? And there was a lot of hype about life sciences, around the sequencing of the human genome and a lot of people concluded that's not really there. But by the way, there was a lot of hype around the digital revolution just about the time of 2000 and the human genome, and it turns out that some of the world's biggest, most powerful companies are the survivors post that crash.