Almost everything I do when I approach an operational problem comes from the time I've been in space. It's a way of organizing your thoughts. We use problem-solving; what we call "what-if-ing." What if this happened? What would we do? We go over plan B, C, D, E, F, and whatever else, depending on the criticality of what we're doing. This kind of thing can be applied almost everywhere, even at home.

I really believe that, in 500 years, we will still remember the International Space Station, because it will have been the first time, really and truly, that nations put a lot of money, brains, resources, and effort together to build something peacefully, and to work together for the sole and unique purpose of furthering our knowledge and bringing it back to Earth for our mutual good.

If anything, when you're up in space and you're inside a space ship, which is your home, and without which you would not survive, you know that Earth is your home. This is the only place you can return. In fact we're very meticulous. Part of our job is to maintain the spaceship. If we apply the same kind of model to Earth maybe we'd have a different outlook.

On the day a country decides not to invest a cent in innovation, discovery or exploration, that country decides to be a tributary to others.

Definitely you don't become famous by doing something bad; that's a professional death sentence.

My husband and I don't worry about each other the way we might if we didn't have similar jobs. I sometimes get an email where he tells me he's heading off on a mission to do terrain avoidance 50 feet above the ground at 500 knots. And I just say, "Okay, have a good flight."

When you're a little different than others, it takes a little more time to fit in. If you really want to be there, there are no ingredients you need other than effort, perseverance and teamwork.