Exactly halfway between exegesis and practical theology stands dogmatics.
Man can certainly flee from God... but he cannot escape him. He can certainly hate God and be hateful to God, but he cannot change into its opposite the eternal love of God which triumphs even in his hate.
Radically and basically, all sin is simply ingratitude.
Men have never been good, they are not good and they never will be good.
True theology is an actual determination and claiming of man by the acting God.
'joy' in Phillippians is a defiant 'Nevertheless!' that Paul sets like a full stop against the Philippians' anxiety.