Science does not rest upon solid bedrock. The bold structure of its theories rises, as it were, above a swamp. It is like a building erected on piles. The piles are driven down from above into the swamp, but not down to any natural or 'given' base; and if we stop driving the piles deeper, it is not because we have reached firm ground. We simply stop when we are satisfied that the piles are firm enough to carry the structure, at least for the time being.

It must be possible for an empirical system to be refuted by experience.

There will be well-testable theories, hardly testable theories, and non-testable theories. Those which are non-testable are of no interest to empirical scientists. They may be described as metaphysical.

Good tests kill flawed theories; we remain alive to guess again.

We should realize that, if [Socrates] demanded that the wisest men should rule, he clearly stressed that he did not mean the learned men; in fact, he was skeptical of all professional learnedness, whether it was that of the philosophers or of the learned men of his own generation, the Sophists. The wisdom he meant was of a different kind. It was simply the realization: how little do I know! Those who did not know this, he taught, knew nothing at all. This is the true scientific spirit.

Optimism is a duty. The future is open. It is not predetermined. No one can predict it, except by chance. We all contribute to determining it by what we do. We are all equally responsible for its success.

. . . it seems to me certain that more people are killed out of righteous stupidity than out of wickedness.