It is impossible to speak in such a way that you cannot be misunderstood.

It is clear that everybody interested in science must be interested in world 3 objects. A physical scientist, to start with, may be interested mainly in world 1 objects--say crystals and X-rays. But very soon he must realize how much depends on our interpretation of the facts, that is, on our theories, and so on world 3 objects. Similarly, a historian of science, or a philosopher interested in science must be largely a student of world 3 objects.

We know a great deal, but our ignorance is sobering and boundless. With each step forward, with each problem which we solve, we not only discover new and unsolved problems, but we also discover that where we believed that we were standing on firm and safe ground, all things are, in truth, insecure and in a state of flux.

[The aim of science is] to explain what so far has taken to be an explicans, such as a law of nature. The task of empirical science constantly renews itself. We may go on forever, proceeding to explanations of a higher and higher universality.

There can be no ultimate statements science: there can be no statements in science which can not be tested, and therefore none which cannot in principle be refuted, by falsifying some of the conclusions which can be deduced from them.

We should realize that, if [Socrates] demanded that the wisest men should rule, he clearly stressed that he did not mean the learned men; in fact, he was skeptical of all professional learnedness, whether it was that of the philosophers or of the learned men of his own generation, the Sophists. The wisdom he meant was of a different kind. It was simply the realization: how little do I know! Those who did not know this, he taught, knew nothing at all. This is the true scientific spirit.

Science is not a system of certain, or -established, statements; nor is it a system which steadily advances towards a state of finality... And our guesses are guided by the unscientific, the metaphysical (though biologically explicable) faith in laws, in regularities which we can uncover-discover. Like Bacon, we might describe our own contemporary science-'the method of reasoning which men now ordinarily apply to nature'-as consisting of 'anticipations, rash and premature' and as 'prejudices'.