It is the rule which says that the other rules of scientific procedure must be designed in such a way that they do not protect any statement in science against falsification.
Karl PopperScience is the century-old endeavour to bring together by means of systematic thought the perceptible phenomena of this world into as thorough-going an association as possible. To put it boldly, it is the attempt at a posterior reconstruction of existence by the process of conceptualization. Science can only ascertain what is, but not what should be, and outside of its domain value judgements of all kinds remain necessary.
Karl PopperIt is easy to obtain confirmations, or verifications, for nearly every theory-if we look for confirmations. Confirmations should count only if they are the result of risky predictions... A theory which is not refutable by any conceivable event is non-scientific. Irrefutability is not a virtue of a theory (as people often think) but a vice. Every genuine test of a theory is an attempt to falsify it, or refute it.
Karl Popper