Our aim as scientists is objective truth; more truth, more interesting truth, more intelligible truth. We cannot reasonably aim at certainty. Once we realize that human knowledge is fallible, we realize also that we can never be completely certain that we have not made a mistake.

The only way to test a hypothesis is to look for all the information that disagrees with it.

The fundamental thing about human languages is that they can and should be used to describe something; and this something is, somehow, the world. To be constantly and almost exclusively interested in the medium - in spectacle-cleaning - is a result of a philosophical mistake.

There is no pure, disinterested, theory-free observation.

A system is empirical or scientific only if it is capable of being tested by experience. These considerations suggest that not the verifiability but the falsifiability of a system is to be taken as a criterion of demarcation... It must be possible for an empirical or scientific system to be refuted by experience.

We know a great deal, but our ignorance is sobering and boundless. With each step forward, with each problem which we solve, we not only discover new and unsolved problems, but we also discover that where we believed that we were standing on firm and safe ground, all things are, in truth, insecure and in a state of flux.

A system such as classical mechanics may be 'scientific' to any degree you like; but those who uphold it dogmatically - believing, perhaps, that it is their business to defend such a successful system against criticism as long as it is not conclusively disproved - are adopting the very reverse of that critical attitude which in my view is the proper one for the scientist.