Manic-depression distorts moods and thoughts, incites dreadful behaviors, destroys the basis of rational thought, and too often erodes the desire and will to live. It is an illness that is biological in its origins, yet one that feels psychological in the experience of it, an illness that is unique in conferring advantage and pleasure, yet one that brings in its wake almost unendurable suffering and, not infrequently, suicide.

The ancient dialogue between reason and the senses is almost always more interestingly and passionately resolved in favor of the senses.

Without science, there would be no such hope.

Somehow, like so many people who get depressed, we felt our depressions were more complicated and existentially based than they actually were.

Children need the freedom and time to play. Play is not a luxury; the time spent engaged in it is not time that could be better spent in more formal educational pursuits. Play is a necessity.

Knowledge is marvelous, but wisdom is even better.

It took me far too long to realize that lost years and relationships cannot be recovered. That damage done to oneself and others cannot always be put right again.