In depression, your capacity to feel just flattens and disappears and what you feel is pain and a kind of pain that you can't describe to anybody. So it's an isolating pain, a completely isolating pain.

The rites of passage in the academic world are arcane and, in their own way, highly romantic, and the tensions and unplesantries of dissertations and final oral examinations are quickly forgotten in the wonderful moment of the sherry afterward, admission into a very old club, parties of celebration, doctoral gowns, academic rituals, and hearing for the first time "Dr.," rather than "Miss" Jamison.

Curiosity, wonder, and passion are defining qualities of imaginative minds and great teachers...Restlessness and discontent are vital things... Intense experience and suffering instruct us in ways less intense emotions can never do.

Manic-depression distorts moods and thoughts, incites dreadful behaviors, destroys the basis of rational thought, and too often erodes the desire and will to live. It is an illness that is biological in its origins, yet one that feels psychological in the experience of it, an illness that is unique in conferring advantage and pleasure, yet one that brings in its wake almost unendurable suffering and, not infrequently, suicide.

Once a restless or frayed mood has turned to anger, or violence, or psychosis, Richard, like most, finds it very difficult to see it as illness, rather than being willful, angry, irrational or simply tiresome.

I look back over my shoulder and feel the presence of an intense young girl and then a volatile and disturbed young woman, both with high dreams and restless, romantic aspirations

There is an assumption, in attaching Puritan concepts such as 'successful' and 'unsuccessful' to the awful, final act of suicide, that those who 'fail' at killing themselves not only are weak, but incompetent, incapable even of getting their dying quite right.