I live in LA so I worry my kids aren't that connected to Britain, I suppose I don't want them to become American kids. We try to get back three or four times a year. When they go to school they speak with a British-American accent but when they come home to us they go back to their British accent, so I can deal with that.

Grey's' is just a machine. I wasn't really prepared for the epic nature of how popular the show is.

I was asked to be in the last two 'Harry Potter' films and I couldn't do it because I was busy filming 'Grey's Anatomy.

I generally play villains once every three or four years by choice because I get offered villainous roles a lot, because of the way I look and whatever. And I tend to avoid them because I think you can end up in a cul-de-sac of your own making if you're cast in that.

One of my complaints with American TV characters is that they all have a particular schtick, a hook.

I am the god of being messy - I'm trying to get better. I was terrible in my 20s. My kids are much tidier than I am, I don't know where they get it from, maybe their mother.

If a man comes up to me, I'm almost sure he's going to mention Rome, if it's a woman, it'll be 'Grey's Anatomy.'