I really just like acting. I'm not always aware of what is hip and what is popular and what is zeitgeist.

Grey's' is just a machine. I wasn't really prepared for the epic nature of how popular the show is.

I've done movies that I've been advised not to do. 'Dog Soldiers,' the movie I did 11 years ago now, I remember my agent at the time was like, 'You shouldn't do that. It's a weird film about werewolves,' and it became a cult hit.

I suppose I am a frustrated musician so I annoy my family by playing guitar in the house. I used to be into acoustic stuff but my son Joseph is learning drums, so now I have an electric guitar and we play Metallica. We have an amp and a PA in the garage with his drum kit.

I generally play villains once every three or four years by choice because I get offered villainous roles a lot, because of the way I look and whatever. And I tend to avoid them because I think you can end up in a cul-de-sac of your own making if you're cast in that.

One of my complaints with American TV characters is that they all have a particular schtick, a hook.

If a man comes up to me, I'm almost sure he's going to mention Rome, if it's a woman, it'll be 'Grey's Anatomy.'