I was asked to be in the last two 'Harry Potter' films and I couldn't do it because I was busy filming 'Grey's Anatomy.

I generally play villains once every three or four years by choice because I get offered villainous roles a lot, because of the way I look and whatever. And I tend to avoid them because I think you can end up in a cul-de-sac of your own making if you're cast in that.

It's a roll of the dice in the movie business. I mean, every single movie is a roll of the dice. Any movie on paper could look like it's going to be fantastic. You know what I mean?

If a man comes up to me, I'm almost sure he's going to mention Rome, if it's a woman, it'll be 'Grey's Anatomy.'

I am the god of being messy - I'm trying to get better. I was terrible in my 20s. My kids are much tidier than I am, I don't know where they get it from, maybe their mother.

One of my complaints with American TV characters is that they all have a particular schtick, a hook.

I've done movies that I've been advised not to do. 'Dog Soldiers,' the movie I did 11 years ago now, I remember my agent at the time was like, 'You shouldn't do that. It's a weird film about werewolves,' and it became a cult hit.