In general, I don't know when inspiration will pop up.
We should not have assumed that a political space station could be built.
I love superconductors.
How much intelligence does it take to sneak up on a leaf?
As for AIDS, it's a plague. We are human, we get plagues. They come along every so often, kill off two thirds of the population; in the next generation it's a quarter; after that it's a childhood disease.
I don't have a strong interest in history.