If we wish to draw philosophical conclusions about our own existence, our significance, and the significance of the universe itself, our conclusions should be based on empirical knowledge. A truly open mind means forcing our imaginations to conform to the evidence of reality, and not vice versa, whether or not we like the implications.

You couldn't be here if stars hadn't exploded, because the elements - the carbon, nitrogen, oxygen, iron, all the things that matter for evolution - weren't created at the beginning of time. They were created in the nuclear furnaces of stars, and the only way they could get into your body is if the stars were kind enough to explode. So, forget Jesus. The stars died so that you could be here today.

The illusion of purpose and design is perhaps the most pervasive illusion about nature that science has to confront on a daily basis.

You are all stardust.

Science has been effective at furthering our understanding of nature because the scientific ethos is based on three key principles: (1) follow the evidence wherever it leads; (2) if one has a theory, one needs to be willing to try to prove it wrong as much as one tries to prove that it is right; (3) the ultimate arbiter of truth is experiment, not the comfort one derives from one's a priori beliefs, nor the beauty or elegance one ascribes to one's theoretical models.

The universe does not care what we want.

I can't prove that God doesn't exist, but I'd much rather live in a universe without one.