During the time that [Karl] Landsteiner gave me an education in the field of imununology, I discovered that he and I were thinking about the serologic problem in very different ways. He would ask, What do these experiments force us to believe about the nature of the world? I would ask, What is the most. simple and general picture of the world that we can formulate that is not ruled by these experiments? I realized that medical and biological investigators were not attacking their problems the same way that theoretical physicists do, the way I had been in the habit of doing.
Linus PaulingYou have to have a lot of ideas. First, if you want to make discoveries, it's a good thing to have good ideas. And second, you have to have a sort of sixth sense-the result of judgment and experience-which ideas are worth following up. I seem to have the first thing, a lot of ideas, and I also seem to have good judgment as to which are the bad ideas that I should just ignore, and the good ones, that I'd better follow up.
Linus PaulingAn amino acid residue (other than glycine) has no symmetry elements. The general operation of conversion of one residue of a single chain into a second residue equivalent to the first is accordingly a rotation about an axis accompanied by translation along the axis. Hence the only configurations for a chain compatible with our postulate of equivalence of the residues are helical configurations.
Linus Pauling